The Benefits in Stem Cells From Umbilical Cord Tissue

We all know that stem cells can be collected from cord blood as well as cord tissue. What many people are not aware of is, what the differences between them are and which one makes a better option for people, who are considering stem cell banking. The cells collected from cord tissue is a comparatively new concept, compared to cord blood stem cells. Let’s decode what they actually mean.

Cord blood is the blood, which is found in the umbilical cord as well as the placenta after a baby is born. When the umbilical cord is clamped and cut, it leaves with approximately two ounces of blood. Medical practitioners collect this blood with a surgical needle. These blood cells are full of adult stem cells, which form our immune and blood system. These are collected, processed and preserved, so they can be used in clinical trials.

On the other hand, cord tissue is the jolly-like material that is found around the vessels of the newborn’s umbilical cord. After the umbilical cord is clamped and cut, a part of the cord is saved to collect these tissue. These tissues contain thousands of different kind of stem cells that have the ability to form our cartilage, circulatory tissues, skin, bone, nervous system and sensory organs.

Now let’s come back to the original question, what are the benefits of stem cells, collected from umbilical cord tissue over cord blood? Apart from having the amazing regenerative qualities, cord tissues have other advantages as well. They have the healing quality to repair our body tissues and give birth to a new self. Listed below are some of the advantages that cord tissue stem cells have.

They are young: The stem cells that are collected from the cord tissue are young and once processed and preserved they can defy aging as well. They not only can create other types of new cells, but also can transform into one of many cell types. These are the qualities that make their aging process slower. Moreover, the agelessness of these cells can also lead to lesser risk of immune response, compared to the aged cells where the chances of chronic complications are high.

They are easy to collect: As mentioned earlier, the collection process of cord tissue is simple and poses no risk to the mother as well as the baby. After the baby is born, the doctors carefully clump and cut the umbilical cord and then they extract the cord blood from the cord. Following this procedure, they take a small portion of the cord for processing and preservation to get the cells.

They are higher in number: It’s noticed that stem cells found from the umbilical cord tissue are much higher than cord blood and other sources. Some studies even proved that the cell count is 3 to 14 times higher in the tissues of the cord. It increases the chance of greater number of cell collection.

They are more productive: The cells from tissues of umbilical cord are more productive than that of other sources. It means that they have more regenerative abilities compared to other sources.

They have migratory abilities: Umbilical cord tissue stem cells can transport straight to the affected areas.

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Say Hello to IPSCORE, New and Improved Tools for Stem Cell Research

According to a recent study, published in Stem Cell Reports on April 6, a new set of improved tools are here to advance stem cell researches. The study was led by Dr. Kelly Frazer, the professor of pediatrics and director of the Institute for Genomic Medicine at University of California San Diego School of Medicine. The team described the collection of “222 systematically derived and characterized iPSC lines generated as part of the National Heart, Lung and Blood Institute’s NextGen consortium.”

The Stem Cell Reports is one of the four studies, published by four different teams of researchers. But Frazer is the common factor in all four as he is senior author for all of them. The fourth study concentrated on iPSCORE, whereas the other three studies utilized the iPSCORE resource in order to explore answers to different questions related to human genetics. Some of the studies also focused on developing new tools to analyze iPSC lines.

The study confirmed that the induced pluripotent stem cells or iPSCs are collected from human adult cells. These cells are able to be differentiated in order to transform into a variety of cell types. By using this attribute, the scientists will be able to use the tool for all critical medical trails; from analyzing molecular processes that cause diseases to genetic variants that lead to human phenotypes.

According to Kelly Frazer, the iPSC Collection for Omic Research or iPSCORE is a collection that will be capable to address various issues that are currently disturbing iPSCs use as a standard system to study human genetics.

He mentioned in the study, “The iPSCORE collection contains 75 lines from people of non-European ancestry, including East Asian, South Asian, African American, Mexican American, and Multiracial. It includes multigenerational families and monozygotic twins. This collection will enable us to study how genetic variation influences traits, both at a molecular and physiological level, in appropriate human cell types, such as heart muscle cells. It will help researchers investigate not only common but also rare, and even family-specific variations.”

Frazer and his team utilized the entire genome sequencing and gene expression analyzing 215 human iPSC lines, derived from different donors. The idea was to identify genetic variants related to RNA expression for 5,746 genes. The study highlighted that iPSCs are valuable to analyze genetic association investigate gene expression genetic regulation in pluripotent stem cells (PSCs). The team also showed important analysis and insights into aberrant methylation patterns in iPSCs. The patterns are helpful to use these cells in various studies as well as to treat diseases.

Another important thing to note in the study is, Frazer and his team built a set of easy-to-use techniques to decrease the cost and at the same time increase the production of effective iPSC lines. In other words, the group of scientists has invented a less expensive technique to develop highly effective iPSC lines. So, the invention will not only help the doctors to detect the source of the disease effectively, but also will help the medical teams to opt for it.